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The theranostic potential of (225)Ac-based radiopharmaceuticals continues to increase as researchers seek innovative ways to harness the nuclear decay of this radioisotope for therapeutic and imaging applications. This communication describes the evaluation of (225)Ac-DOTA-c(RGDyK) in both biodistribution and Cerenkov luminescence imaging (CLI) studies. Initially, La-DOTA-c(RGDyK) was prepared as a non-radioactive surrogate to evaluate methodologies that would contribute to an optimized radiochemical synthetic strategy and estimate the radioactive conjugate's affinity for αvβ3, using surface plasmon resonance spectroscopy. Surface plasmon resonance spectroscopy studies revealed the IC50 and Ki of La-DOTA-c(RGDyK) to be 33 ± 13 nM and 26 ± 11 nM, respectively, and suggest that the complexation of the La3+ ion to the conjugate did not significantly alter integrin binding. Furthermore, use of this surrogate allowed optimization of radiochemical synthesis strategies to prepare (225)Ac-DOTA-c(RGDyK) with high radiochemical purity and specific activity similar to other (225)Ac-based radiopharmaceuticals. This radiopharmaceutical was highly stable in vitro. In vivo biodistribution studies confirmed the radiotracer's ability to target αvβ3 integrin with specificity; specificity was detected in tumor-bearing animals using Cerenkov luminescence imaging. Furthermore, tumor growth control was achieved using non-toxic doses of the radiopharmaceutical in U87mg tumor-bearing nude mice. To our knowledge, this is the first report to describe the CLI of αvβ3+ tumors in live animals using the daughter products derived from (225)Ac decay in situ. This concept holds promise to further enhance development of targeted alpha particle therapy. PMID:27022417

On Mac OS X (example): In /Applications/Microsoft Office 2011/ you can find Microsoft Office Access Database Engine 2010 Redistributable. So, just copy it and paste it to /Applications/Microsoft Office 2011/Office (or press Command +] and go to the folder /Applications/Microsoft Office 2011/Office)

I did ofc. I also installed it and It works i just wanted to know this beforehand. For people who havent had any version of serum before these folders just dont exist and the instructions are kind of misleading.

This is what i did, and nothing changed.

I also downloaded a sample and tried to extract the files, and this is what i did:

Samples>Serum Album Artist>Samples>Serum Album Artist>Serum Album - Classic

I did ofc. I also installed it and It works i just wanted to know this beforehand. For people who havent had any version of serum before these folders just dont exist and the instructions are kind of misleading.

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