Sandra Teen Model Early Sets Img 12 |VERIFIED|
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Figure 2 Advanced age and DIO induce convergent inflammatory alterations within the tumor-adjacent mammary adipose in a metM-Wntlung cell transplant model of TNBC. (A) Hallmark gene sets commonly enriched in tumor-adjacent mammary fat pad (TA-MFP) of aged control versus young control and young DIO vs young control mice determined following gene set enrichment analysis (GSEA). (B) Leading edge analysis (LEA) of immune-related Hallmark gene sets commonly enriched. (C) Frequency of genes occurring in the leading edge of commonly enriched, immune-related Hallmark gene sets versus gene rank. (D) C7 Immunologic gene sets commonly enriched in TA-MFP of aged control vs young control and young DIO vs young control micedetermined following GSEA. (E) LEA of all C7 gene sets commonly enriched. (F) Frequency of genes occurring in the leading edge of commonly enriched C7 gene sets versus gene rank. (G) Heat map of select leading edge genes. Significantly enriched gene sets defined as FDR q-value 2b1af7f3a8